p-Coumaric Acid Potently Down-regulates Zebrafish Embryo Pigmentation: Comparison ofin vivoAssay and Computational Molecular Modeling with Phenylthiourea
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منابع مشابه
Phenylthiourea as a weak activator of aryl hydrocarbon receptor inhibiting 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 transcription in zebrafish embryo.
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that can be activated by a diverse synthetic and naturally-occurring chemicals, such as the halogenated aromatic hydrocarbons (HAHs) and the non-halogenated polycyclic aromatic hydrocarbons (PAHs). The liganded AHR modulates the genetic activity of a variety of xenobiotic-responsive genes, including cytochrome P4501A...
متن کاملPhenylthiourea Specifically Reduces Zebrafish Eye Size
Phenylthiourea (PTU) is commonly used for inhibiting melanization of zebrafish embryos. In this study, the standard treatment with 0.2 mM PTU was demonstrated to specifically reduce eye size in larval fish starting at three days post-fertilization. This effect is likely the result of a reduction in retinal and lens size of PTU-treated eyes and is not related to melanization inhibition. This is ...
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BACKGROUND Colorectal cancer (CRC) or bowel cancer is one of the most important cancer diseases, needing serious attention. The cell surface receptor gene human epidermal growth factor receptor (EGFR) may have an important role in provoking CRC. In this pharmaceutical era, it is always attempted to identify plant-based drugs for cancer, which will have less side effects for human body, unlike t...
متن کاملp-Coumaric acid inhibition of CREB phosphorylation reduces cellular melanogenesis
We investigated the in vitro effects of p-coumaric acid on melanogenesis. The melanin content in B16F1 cells stimulated with p-coumaric acid significantly decreased (68 % vs. control) through inhibition of tyrosinase enzyme activity assessed using both cell-free and cellbased assays (46 and 27 % compared with control, respectively). In addition, stimulating B16F1 cells with p-coumaric acid redu...
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ژورنال
عنوان ژورنال: Biomedical Science Letters
سال: 2017
ISSN: 2288-7415
DOI: 10.15616/bsl.2017.23.1.8